Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1STEM Mouse
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- 作者：Francois E. Mercier1 ; 2 ; 3 ; fmercier@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; David B. Sykes1 ; 2 ; 3 ; David T. Scadden1 ; 2 ; dscadden@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：6
- 期：6
- 页码：985-992
- 全文大小：1043 K
文摘
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Competitive transplantation is a fundamental tool for examining HSPC biology
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The congenic interval of the B6.SJL-Ptprca Pepcb/BoyJ mouse affects HSPC function
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CD45.1 and CD45.2 epitopes differ by one amino acid
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A single amino acid change in the C57BL/6N strain creates the CD45.1STEM competitor