Systematic study of the reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different classes of nucleophiles
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- 作者：Elsa Forcellini ; Ré ; my Hemelaere ; Justine Desroches ; Jean-Franç ; ois Paquin ; jean-francois.paquin@chm.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trifluoromethyl group ; Allylic tosylate ; Substitution reaction ; Nucleophile ; Allylic substitution
- 刊名：Journal of Fluorine Chemistry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：180
- 期：Complete
- 页码：216-221
- 全文大小：525 K
文摘
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The reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different nucleophiles was performed.
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Phenol, amines, thiols, and malonates all provide the substitution product in moderate to excellent yields.
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Benzyl alcohol and indole provide low yield of the desired product.