The relationship between adipokines and the onset of type 2 diabetes in middle-aged men: The PRIME study

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• 作者：Charlotte E. Neville^a ; ^{c.neville@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Christopher C. Patterson^a ; ^b ; ^{c.patterson@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Gerard J. Linden^a ; ^{g.linden@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Karl Love^a ; ^{klove01@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Michelle C. McKinley^a ; ^b ; ^{m.mckinley@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Frank Kee^a ; ^b ; ^{f.kee@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Stefan Blankenberg^c ; ^{s.blankenberg@uke.de" class="auth_mail" title="E-mail the corresponding author} ; Alun Evans^a ; ^{a.evans@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; John Yarnell^a ; ^{j.yarnell@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Jayne V. Woodside^a ; ^b ; ^{j.woodside@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Adiponectin ; Leptin ; Type 2 diabetes ; Prospective study
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：120
• 期：Complete
• 页码：24-30
• 全文大小：407 K

文摘

Epidemiological evidence suggests that adipokines may be associated with the onset of type 2 diabetes, but the evidence to date is limited and inconclusive. This study examined the association between adiponectin and leptin and the subsequent diagnosis of type 2 diabetes in a UK population based cohort of non-diabetic middle-aged men.

Methods

Baseline serum levels of leptin and adiponectin were measured in 1839 non-diabetic men aged 50–60 years who were participating in the prospective population-based PRIME study. Over a mean follow-up of 14.7 years, new cases of type 2 diabetes were determined from self-reported clinical information with subsequent validation by general practitioners.

Results

151 Participants developed type 2 diabetes during follow-up. In Cox regression models adjusted for age, men in the top third of the leptin distribution were at increased risk (hazard ratio (HR) 4.27, 95% CI 2.67–6.83) and men in the top third of the adiponectin distribution at reduced risk (HR 0.24, 95% CI 0.14–0.42) relative to men in the bottom third. However, significance was lost for leptin after additional adjustment for BMI, waist to hip ratio, lifestyle factors and biological risk factors, including C-reactive protein (CRP). Further adjustment for HOMA-IR also resulted in loss of significance for adiponectin.

Conclusions

This study provides evidence that adipokines are associated with men’s future type 2 diabetes risk but not independently of other risk factors.