Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses

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• 作者：Shringkhala Bajimaya ; Tsuyoshi Hayashi ; Tü ; nde Frankl ; Peter Bryk ; Brian Ward ; Toru Takimoto ; ^{toru_takimoto@urmc.rochester.edu}
• 关键词：Type I parainfluenza virus ; Assembly ; Cholesterol ; Lipid rafts ; Antiviral therapy
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：127-135
• 全文大小：1389 K
• 卷排序：501

文摘

Cholesterol-reducing agents inhibit production of infectious hPIV1 and SeV. The drugs block virus assembly and release from infected cells. Cholesterol is required for assembly and formation of parainfluenza viruses.