Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis

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• 作者：Karina Formoso ; Micaela D Garcia ; Alberto C Frasch ; Camila Scorticati ; ^{cscorticati@iib.unsam.edu.ar}
• 关键词：PLP family ; Transmembrane domains ; Synapses ; nsSNPs variants ; Dendritic arborization
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：77
• 期：Complete
• 页码：95-104
• 全文大小：1758 K
• 卷排序：77

文摘

Endogenous M6a participates in synapses closely related to both synaptophysin and NMDA-R1 puncta in vitro. M6a overexpressing neurons show an increase in dendritic spines and synapses. Two nsSNPs present in GPM6A are unable to induce both synapses and dendritic spines.