THE MEDICAL RESEARCH COUNCIL TRIALS IN ADULT ACUTE LYMPHOCYTIC LEUKEMIA

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• 作者：I. Jill Durrant ; MB BS (Lond) ; FRCPath ; DCH^a ; Susan M. Richards ; MA (Oxon) ; DPhil^a ; H. Grant Prentice ; MB BS ; (Lond) ; FRCP ; FRCPath^b ; Anthony H. Goldstone ; BM BCh (Oxon) ; MA (Oxon) ; FRCP ; FRCPath^c
• 刊名：Hematology/Oncology Clinics of North America
• 出版年：2000
• 出版时间：1 December 2000
• 年：2000
• 卷：14
• 期：6
• 页码：1327-1352
• 全文大小：1198 K

文摘

The Medical Research Council (MRC) Leukaemia Steering Committee was formed by interested hematologists, physicians, pediatricians, and statisticians in the late 1950s to consider the treatment of children and adults with acute leukemia, with a view to establishing randomized clinical trials. The Leukaemia Steering Committee set up two working parties in acute leukemia, in children and adults. The Adult Working Party was set up in 1957; a list of the members is set out in Appendix 1. The chairman of the committee was Professor Leslie Witts and the secretary was Professor D.A.G. Galton. The first randomized trial, comparing steroid therapy at high and low dosage in conjunction with 6-mercaptopurine, was published in the British Medical Journal on January 5, 1963, in an article entitled ¡°Treatment of Acute Leukaemia in Adults: Comparison of Steroid Therapy at High and Low Dosage in Conjunction with 6-Mercaptopurine.?p>In 1957 a Steering Committee for the evaluation of different methods of cancer therapy was set up by the Medical Research Council. The Committee was assembled in the first instance because of the need for an assessment of the newer forms of radiotherapy. Although the treatment of leukaemia had not been as much affected by the introduction of these methods as other forms of malignant disease, it was considered that current forms of treatment were in need of critical appraisal. The Committee recommended that six Working Parties should be formed, and that one of them should examine the possibilities of carrying out therapeutic trials in leukaemia. The trial here reported was the first of three begun on the recommendation of a Working Party which included representatives of hospitals in London, Cambridge, Oxford, Sheffield, Leeds, Manchester, and Newcastle.

The Childhood Leukaemia Working Party initiated the United Kingdom Acute Lymphocytic Leukaemia (UKALL) I trial in August 1970, and reported its first results in November 1972. All children aged 1 through 13 years in the United Kingdom were eligible.

The Working Party on Leukaemia in Adults set up multicenter trials throughout the United Kingdom (i.e., England, Wales, Scotland, and Northern Ireland) in acute and chronic myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, and polycythemia rubra vera at about the same time, but adult patients with acute lymphoblastic leukemia were enrolled in the childhood trials UKALL I through V. This practice continued until UKALL Trial VI in 1978, which was intended for both adults and children. The first entirely adult trial (for persons over 15 years), UKALL Trial IX, started in 1980. Since then, two other trials, UKALL XA (1985) and UKALL XII (1993), have been open to persons over 15 years of age. Professor Kay coordinated UKALL IX, Drs. Jill Durrant and Grant Prentice coordinated UKALL XA, and Professors Tony Goldstone, Ian Franklin, Grant Prentice, and Dr. Jill Durrant coordinated UKALL XII.

The membership of the Working Party on Leukaemia in Adults for the year 2000 is given in Appendix 2.