- 作者：Pietro Santulli ; M.D.a ; b ; c ; pietro.santulli@inserm.fr ; Bruno Borghese ; M.D. ; Ph.D.a ; c ; Sandrine Chouzenouxb ; Isabelle Streuli ; M.D.a ; b ; Didier Borderie ; M.D. ; Ph.D.d ; Dominique de Ziegler ; M.D.a ; Bernard Weill ; M.D. ; Ph.D.b ; Charles Chapron ; M.D.a ; b ; c ; Frederic Batteux ; M.D. ; Ph.D.b
- 关键词：IL-19 ; IL-22 ; endometrioma ; cytokines ; inflammation ; pathogenesis
- 刊名：Fertility and Sterility
- 出版年：2013
- 出版时间：January, 2013
- 年：2013
- 卷：99
- 期：1
- 页码：219-226.e2
- 全文大小：291 K
Objective
To determine the serum levels of interleukin (IL)-10 family ILs in women with ovarian endometriosis and investigate the correlation of these levels with disease activity.Design
A case-control laboratory study.
Setting
Tertiary-care university hospital.
Patient(s)
Two hundred nineteen women, with (n?=?112) and without (n?=?107) endometriosis.
Intervention(s)
Complete surgical excision with pathological analysis.
Main Outcome Measure(s)
Blood samples were obtained during surgical procedures. IL-10, -19, -20, and -22 were assayed by ELISA in sera, and the concentrations correlated with the extent and the severity of the disease.
Result(s)
IL-19 was detectable in 18.3 % and IL-22 in 47.9 % of sera samples from all 219 women studied. Serum IL-19 was lower in women with endometriosis (median, 292.7 pg/mL; range, 32.2-1,339.3) than in endometriosis-free women (median, 1,035.8 pg/mL; range, 32.2-2,000.0). In addition, serum IL-22 levels were decreased in women affected by endometriosis (median, 352.0 pg/mL; range, 31.2-1,392.2) as compared with endometriosis-free women (median, 709.2 pg/mL; range, 73.3-2,012.0). We found significant correlations between serum IL-22 concentrations and intensity of deep dyspareunia (r?=??0.303) and noncyclic chronic pelvic pain (r?=??0.212). IL-19 was correlated with the intensity of deep dyspareunia (r?=??0.749).
Conclusion(s)
Serum IL-19 and IL-22 are decreased in women with ovarian endometrioma. IL-10 family ILs may be involved in the pathogenesis of endometriosis.