Adverse clinical interaction between amiodarone and HCV-NI drugs is captured by in vitro models.
Human iPSC-derived cardiomyocyte beating syncytial model points to Ca2 + handling effects.
Overexpressing human Ca2 + channel line model points to shifts in Ca2 + influx.
Shifts in Ca2 + current voltage-dependent inactivation play a role in the AER interaction.