Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells
详细信息 查看全文
- 作者：Armando Lagrutta ; PhD ; armando_lagrutta@merck.com" class="auth_mail" title="E-mail the corresponding author ; Haoyu Zeng ; PhD ; John Imredy ; PhD ; Bharathi Balasubramanian ; MS ; Spencer Dech ; MA ; Edward Lis ; BS ; Jixin Wang ; MS ; Jin Zhai ; MS ; Joseph DeGeorge ; PhD ; Frederick Sannajust ; PharmD ; PhD
- 关键词：AMIO ; amiodarone ; CCBs ; calcium channel blockers ; DEA ; desethylamiodarone ; DDI ; drug-drug interaction(s) ; DRON ; dronedarone ; FP ; field potential ; HCV-NI ; hepatitis-C virus nucleotide inhibitor ; hiPSC-CMs ; human induced Pluripotent Stem Cell-derived Cardiomyocytes ; IMP ; impedance ; MNI-1 ; Merck-Nucleotide Inhibitor #1 ; NCX1 ; sodium-calcium exchanger 1 ; P-gp ; P-glycoprotein ; SERCA ; sarcoplasmic-endoplasmic reticulum calcium-ATPase ; SOF ; sofosbuvir
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：66-76
- 全文大小：2284 K
文摘
- ass="listitem" id="list_l0005">
- ass="label">•
Adverse clinical interaction between amiodarone and HCV-NI drugs is captured by in vitro models.
- ass="label">•
Human iPSC-derived cardiomyocyte beating syncytial model points to Ca2 + handling effects.
- ass="label">•
Overexpressing human Ca2 + channel line model points to shifts in Ca2 + influx.
- ass="label">•
Shifts in Ca2 + current voltage-dependent inactivation play a role in the AER interaction.