Exhaled Molecular Fingerprinting in Diagnosis and Monitoring: Validating Volatile Promises

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• 作者：Agnes W. Boots¹ ; ^{a.boots@maastrichtuniversity.nl" class="auth_mail" title="E-mail the corresponding author} ; Lieuwe D. Bos² ; Marc P. van der Schee² ; ³ ; Frederik-Jan van Schooten¹ ; Peter J. Sterk²
• 关键词：Breath ; diagnosis ; eNose ; GC-MS ; metabolomics ; volatile organic compounds
• 刊名：Trends in Molecular Medicine
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：21
• 期：10
• 页码：633-644
• 全文大小：1837 K

文摘

Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes. After recent proof of concept studies demonstrating moderate to good diagnostic accuracies, the latest efforts in breathomics are focused on optimization of sensor technologies and analytical algorithms, as well as on independent validation of clinical classification and prediction. Current research strategies are revealing the underlying pathophysiological pathways as well as clinically-acceptable levels of diagnostic accuracy. Implementing recent guidelines on validating molecular signatures in medicine will enhance the clinical potential of breathomics and the development of point-of-care technologies.