Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology

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• 作者：Shaofeng Wei^a ; ¹ ; Yueqin Ma^b ; ¹ ; Jing Luo^a ; Xiaoru He^a ; Pengfei Yue^a ; ^{feigleYue@outlook.com} ; Zhiyu Guan^a ; Ming Yang^a
• 关键词：Hydroxypropylcellulose ; Nanocrystals ; Cage-like microparticles ; Spray-freeze-drying ; Redispersibility
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：953-961
• 全文大小：3486 K
• 卷排序：157

文摘

A novel cage-like composite particles used HPC as carrier was developed. An interesting strategy by means of spray-freeze-drying technique was used. The spray-freeze-dried CMs exhibited excellent dissolution-enhanced specialty. HPC was demonstrated to be an effective matrix carrier for drug nanocrystals.