Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes
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- 作者：Marco van der Toorn ; 1 ; Marco.vanderToorn@pmi.com" class="auth_mail" title="E-mail the corresponding author ; Stefan Frentzel1 ; Stefan.Frentzel@pmi.com" class="auth_mail" title="E-mail the corresponding author ; Hector De Leon hdeleon68@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Didier Goedertier Didier.Goedertier@pmi.com" class="auth_mail" title="E-mail the corresponding author ; Manuel C. Peitsch Manuel.Peitsch@pmi.com" class="auth_mail" title="E-mail the corresponding author ; Julia Hoeng Julia.Hoeng@pmi.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transendothelial migration ; THP-1 cells ; Endothelial cells ; Atherosclerosis ; Modified risk tobacco product ; Tobacco-heating system
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：86
- 期：Complete
- 页码：81-87
- 全文大小：1457 K
文摘
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Transendothelial migration of monocytes is accompanied by significant changes in adhesion and expression of MAC-1.
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Extracts from the tobacco heating system (THS) 2.2 induce less inflammation and migration and are less cytotoxic than those from burning conventional cigarettes.
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Reduction in the exposure to harmful constituents using heated rather than burning tobacco could be a promising new approach to reduce the harmful effects associated with cigarette smoking.