NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy
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- 作者：Alix Warburtona ; Fabio Miyajimaa ; Kanvel Shazadia ; Joanne Crossleya ; Michael R. Johnsonb ; Anthony G. Marsona ; Gus A. Bakera ; John P. Quinna ; Graeme J. Sillsa ; g.sills@liv.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AED ; antiepileptic drug ; AMIPB ; Adult Memory and Information Processing Battery ; AVLT ; Auditory Verbal Learning Task ; β ; beta coefficient ; BDNF ; brain-derived neurotrophic factor ; CI ; confidence interval ; CVST ; Computerized Visual Search Task ; HWE ; Hardy&ndash ; Weinberg equilibrium ; htSNP ; haplotype-tagging SNP ; LD ; linkage disequilibrium ; MAF ; minor allele frequency ; NRSF ; neuron-restrictive silencer factor ; SNP ; single nucleotide polymorphism ; REML ; Restricted Maximum Likelihood ; REST ; restrict
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：117-127
- 全文大小：1181 K
文摘
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Cognitive dysfunction is a common and important comorbidity in people with epilepsy.
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Causes of cognitive problems are unknown, but genetics may be involved.
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We compared NRSF and BDNF gene variants with cognition in new-onset epilepsy.
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Deterioration in memory task scores from baseline was associated with genotype.
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The NRSF/BDNF pathway may be relevant to cognitive function in people with epilepsy.