Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria
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- 作者：Freudenberg ; Marina A. ; Merlin ; Thomas ; Gumenscheimer ; Marina ; Kalis ; Christoph ; Landmann ; Regine ; et. al.
- 关键词：LPS susceptibility ; lps gene ; TNF-α ; Salmonella typhimurium infection ; LPS-binding protein ; TLR4 ; CD14 ; IFN-γ ; IL-12
- 刊名：Microbes and Infection
- 出版年：2001
- 出版时间：November - December, 2001
- 年：2001
- 卷：3
- 期：14-15
- 页码：1213-1222
- 全文大小：283 K
文摘
Lipopolysaccharide is an important recognition marker by virtue of which the innate immune system senses and reacts against Gram-negative bacteria invading the LPS susceptible host. This review deals with the factors affecting LPS susceptibility and with the role of the latter in the course and outcome of Salmonella typhimurium infection.