Vitamin D in the treatment of pulmonary tuberculosis
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- 作者：Adrian R. Martineau ; Friedemann U. Honecker ; Robert J. Wilkinson ; Christopher J. Griffiths
- 关键词：Vitamin D ; Tuberculosis ; Paradoxical reaction ; Hypercalcemia
- 刊名：The Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2007
- 出版时间：March 2007
- 年：2007
- 卷：103
- 期：3-5
- 页码：793-798
- 全文大小：221 K
文摘
Vitamin D was used to treat tuberculosis in the pre-antibiotic era. New insights into the immunomodulatory properties of 1α,25-dihydroxy-vitamin D have rekindled interest in vitamin D as an adjunct to antituberculous therapy. We describe the historical use of vitamin D in tuberculosis treatment; discuss the mechanisms by which it may modulate host response to infection with Mycobacterium tuberculosis; and review three clinical trials and ten case series in which vitamin D has been used in the treatment of pulmonary tuberculosis.