Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

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• 作者：Beate Fuchs ; Natascha Sommer ; Alex ; er Dietrich ; Ralph Theo Schermuly ; Hossein Ardeschir Ghofrani ; Friedrich Grimminger ; Werner Seeger ; Thomas Gudermann ; Norbert Weissmann
• 关键词：Hypoxia ; Pulmonary vasculature ; Reactive oxygen species ; Redox state ; Superoxide
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2010
• 出版时间：31 December 2010
• 年：2010
• 卷：174
• 期：3
• 页码：282-291
• 全文大小：630 K

文摘

Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism of the lung that matches blood perfusion with alveolar ventilation to optimize gas exchange. Perturbations of HPV, as may occur in pneumonia or adult respiratory distress syndrome, can cause life-threatening hypoxemia. Despite intensive research for decades, the molecular mechanisms of HPV have not been fully elucidated. Reactive oxygen species (ROS) and changes in the cellular redox state are proposed to link O₂ sensing and pulmonary arterial smooth muscle cell contraction underlying HPV. In this regard, mitochondria and NAD(P)H oxidases are discussed as sources of ROS. However, there is controversy whether ROS levels decrease or increase during hypoxia. With this background we summarize the current knowledge on the role of ROS and redox state in HPV.