The neural correlates and clinical characteristics of psychosis in the frontotemporal dementia continuum and the C9orf72 expansion

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• 作者：Emma M Devenney^a ; ^b ; ^c ; ^d ; ^{e.devenney@neura.edu.au} ; Ramon Landin-Romero^a ; ^b ; ^d ; Muireann Irish^a ; ^b ; ^d ; Michael Hornberger^e ; Eneida Mioshi^e ; Glenda M. Halliday^a ; ^b ; Matthew C. Kiernan^a ; ^b ; ^c ; John R. Hodges^a ; ^b ; ^d
• 关键词：Frontotemporal dementia ; Amyotrophic lateral sclerosis ; C9orf72 expansion ; Psychosis ; Schizophrenia ; Neuroimaging
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：439-445
• 全文大小：870 K
• 卷排序：13

文摘

This study has confirmed a high rate of psychotic symptoms in C9orf72 carriers (64%). Psychotic symptoms are also common in C9orf72 non-carriers (26%). Psychotic symptoms are more severe in C9orf72 carriers than non-carriers. A distributed cortical and subcortical network is associated with increased psychotic symptoms in C9orf72 carriers. The network of affected brain regions is very similar to that seen in other psychotic disorders such as schizophrenia.