The effects of levonorgestrel on FSH-stimulated primary rat granulosa cell cultures through gene expression profiling are associated to hormone and folliculogenesis processes

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• 作者：Saú ; l Lira-Albarrá ; n^a ; ^{saul.liraa@incmnsz.mx} ; Marco F. Larrea-Schiavon^b ; ^{marcof80@gmail.com} ; Leticia Gonzá ; lez^a ; ^{leti1903@yahoo.com.mx} ; Marta Durand^a ; ^{mdurand65@gmail.com} ; Claudia Rangel^b ; ^{crangel@inmegen.gob.mx} ; Fernando Larrea^a ; ^{fernando.larreag@incmnsz.mx}
• 关键词：Contraception ; Gene transcription ; Granulosa cells ; Levonorgestrel
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：337-345
• 全文大小：1367 K
• 卷排序：439

文摘

Levonorgestrel inhibited hFSH-induced estradiol biosynthesis in rat granulosa cells. The mechanism of aromatase inhibition is post-cAMP at the level of gene transcription. Levonorgestrel alters FSH-responsive genes involved in folliculogenesis. Progesterone-mediated oocyte maturation genes are modified by levonorgestrel. The ovary is a target for levonorgestrel contraceptive effects.