Iron gene expression profile in atherogenic Mox macrophages
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- 作者：Liliana Marquesa ; b ; c ; Anne Negre-Salvayred ; Luciana Costab ; c ; 1 ; luciana.costa@insa.min-saude.pt" class="auth_mail" title="E-mail the corresponding author ; Franç ; ois Canonne-Hergauxa ; e ; 1 ; francois.canonne-hergaux@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：acLDL ; acetylated LDL ; ApoE&minus ; /&minus ; ; cells or mice deficient in the gene coding for apolipoprotein E ; ATH ; atherosclerosis ; BMDM ; bone marrow-derived macrophages ; CP/Cp ; ceruloplasmin (gene Cp) ; EDTA ; ethylenediaminetetraacetic acid ; ffe ; flat iron mutation in Fpn gene ; FeNTA ; iron nitrilotriacetate ; FPN/Fpn ; ferroportin (gene Slc40a1 ; alias Fpn) ; FT ; ferritin ; FTH1/Fth1 ; ferritin heavy chain (gene Fth1) ; FTL/Ftl1 ; ferritin light chain (gene Ftl1) ; GPI-CP ; membrane glycosylphosphati
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1862
- 期：6
- 页码：1137-1146
- 全文大小：2230 K
文摘
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Macrophage iron accumulation has been proposed to play a role in atherogenesis.
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We studied iron genes expression under proatherogenic stimuli in mouse macrophages.
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oxLDL and/or LPS/INFγ induced an expression profile consistent with iron retention.
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Despite mRNA upregulation, ferroportin protein levels were not change by oxLDL.
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oxLDL regulation of ceruloplasmin and hepcidin may limit ferroportin levels.