Identification of human ferritin, heavy polypeptide 1 (FTH1) and yeast RGI1 (YER067W) as pro-survival sequences that counteract the effects of Bax and copper in Saccharomyces cerevisiae
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- 作者：Rawan Eida ; b ; 1 ; Eric Boucherc ; 1 ; Nada Ghariba ; 1 ; Chamel Khourya ; b ; c ; Nagla T.T. Araba ; b ; Alistair Murrayc ; Paul G. Youngb ; Craig A. Mandatoc ; Michael T. Greenwooda ; michael.greenwood@rmc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Copper ; Ferritin ; Iron ; Anti-apoptosis ; Pro-survival ; Recombinant ferritin
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：342
- 期：1
- 页码：52-61
- 全文大小：3124 K
文摘
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Human ferritin, heavy polypeptide 1 (FTH1) was identified as a suppressor of the pro-apoptotic Bax in yeast.
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Based on its similarity to ferritin we examined Rgi1p/YER067W for potential ferritin like functions.
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Like human H-ferritin, RGI1 confers increased resistance to apoptotic inducing stresses in yeast.
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Rgi1p is a pro-survival protein that is not a ferritin but that may play a role in iron metabolism of yeast.