Functional and clinical evaluation of renal injury in patients treated with adjuvant chemoradiotherapy for gastric cancer: Low dose and comorbidity considerations

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• 作者：Roman Ibrahimov^a ; Beste M. Atasoy^b ; ^{bmatasoy@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Fuat Dede^c ; Hakki Arikan^d ; Zeynep Ozen^a ; Zerrin Ozgen^e ; Faysal Dane^f ; Ufuk Abacioglu^a
• 关键词：Comorbidity ; Dose volume effect ; Late effect ; Radiotherapy ; Renal toxicity
• 刊名：Journal of Radiation Research and Applied Sciences
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：9
• 期：1
• 页码：63-67
• 全文大小：331 K

文摘

To analyze the dosimetric factors affecting long-term renal function in patients with gastric cancer following postoperative radiotherapy with concomitant chemotherapy to the upper abdomen.

Methods

Between January 2005 and July 2010, 13 patients treated with three-dimensional conformal radiotherapy and concurrent fluorouracil-based chemotherapy (CRT) were included in this analysis. After a median follow-up of 55 months, creatinine, glomerular filtration rate (GFR), total kidney and left kidney volumes, before and after CRT and mercaptoacetyltriglycine (MAG3) scintigraphy, were used to evaluate the renal function and were correlated with the dosimetrics data.

Results

Significant correlations were found in the loss of left kidney volume and V35 (20.6%) (p = 0.035) and V40 (15.7%) (p = 0.031) and in the loss of relative functional contribution of the main kidney and V35 Gy (p = 0.027) and V40 Gy (p = 0.019). In patients with a slightly low basal GFR (n = 6), the relative functional contribution of the left kidney significantly decreased, regardless of the dosage.

Conclusion

Functional renal impairment without any clinical signs or symptoms can be observed in low doses after radiotherapy. Careful treatment planning and a detailed evaluation of the functional renal capacity before treatment may help to reduce late renal toxicity.