The combination of Pleurotus ferulae water extract and CpG-ODN enhances the immune responses and antitumor efficacy of HPV peptides pulsed dendritic cell-based vaccine
详细信息 查看全文
- 作者：Jinyu Li ; Jinyao Li ; ljyxju@xju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Adila Aipire ; JiaoJiao Luo ; Pengfei Yuan ; Fuchun Zhang
- 关键词：CTL ; cytotoxic T lymphocytes ; DCs ; dendritic cells ; iDCs ; immature DCs ; iTregs ; induced regulatory T cells ; mDCs ; mature DCs ; nTregs ; natural regulatory T cells ; PFWE ; Pleurotus ferulae water extract
- 刊名：Vaccine
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：34
- 期：31
- 页码：3568-3575
- 全文大小：1751 K
文摘
- •
HPV-PFWE + CpG-DCs induced highest level of CD8+ T cell responses.
- •
HPV-PFWE + CpG-DCs decreased the frequencies of both iTregs and nTregs.
- •
HPV DC-based vaccines inhibited tumor growth in TC-1 tumor mouse model.