O-fucosylation of CCN1 is required for its secretion
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- 作者：Yuki Niwaa ; Takehiro Suzukib ; Naoshi Dohmaeb ; Siro Simizua ; simizu@applc.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：IGFBP ; insulin-like growth factor-binding protein ; vWC ; von Willebrand factor type C repeat ; TSR1 ; thrombospondin type-1 repeat ; CT ; cysteine knot motif ; HSPG ; heparan sulfate proteoglycan ; EGF ; epidermal growth factor ; ER ; endoplasmic reticulum ; Pofut ; protein O-fucosyltransferase ; CM ; conditioned medium ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; CBB ; Coomassie Brilliant Blue ; PBS ; phosphate-buffered saline
- 刊名：FEBS Letters
- 出版年：2015
- 出版时间：24 October 2015
- 年：2015
- 卷：589
- 期：21
- 页码：3287-3293
- 全文大小：779 K
文摘
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Human CCN1 is O-fucosylated at Thr242.
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10">O-fucosylation-defective mutant of CCN1 decreased the secretion level.
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15">Pofut2-mediated O-fucosylation is required for the secretion of CCN1.
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Secretion of CCN1 is regulated by O-fucosylation.