Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway
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- 作者：Lijie Maa ; 1 ; Pingping Dongb ; 1 ; Longzi Liua ; Qiang Gaoa ; Meng Duana ; Si Zhangc ; She Chenc ; Ruyi Xueb ; xue.ruyi@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaoying Wanga ; xiaoyingwang@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCC ; Protein O-fucosyltransferase 1 ; Proliferation ; Migration ; Notch
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：503-510
- 全文大小：2279 K
文摘
- 10">
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10">Pofut1 overexpression in HCC was correlated with aggressive tumor behaviors.
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15">Pofut1 overexpression in HCC was associated with poor prognosis.
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Pofut1 promoted cell proliferation, migration and invasion in hepatoma cells.
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Pofut1 activated Notch signaling pathway in hepatoma cells.