Box–Behnken design was used to understand the effect of process variables. SFO as co-solvent with SC-CO2 increases the recovery of carotenoid and fucoxanthin. Water as co-solvent with SC-CO2 increases the recovery of phlorotannin. Fatty acid, antioxidant and oil stability was increased with SFO as co-solvent. Kinetic models for all the extraction yield were established.