Quality Analysis of Herbal Medicine Products Prepared from Herba Sarcandrae by Capillary Electrophoresis with Electrochemical Detection

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• 作者：Xiao-guang ZHOU ; Jin-ying SUN ; De-rong ZHU ; Bai-qing YUAN ; Tian-yan YOU
• 关键词：Capillary electrophoresis ; Electrochemical detection ; Chinese patent medicines ; Herba Sarcandrae ; Quality analysis
• 刊名：Chemical Research in Chinese Universities
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：24
• 期：2
• 页码：148-153

文摘

A capillary electrophoresis with electrochemical detection(CE-ED) method was developed for the quality analysis of herbal medicine products prepared from the same herb of Herba Sarcandrae: Fufang Caoshanhu tablets, Qingrexiaoyanning capsules, and Xuekang oral liquids. Under the optimal analysis conditions, the low detection limit[1.0x10⁻⁷ mol/L(S/N=3)] and the wide linear range(1.0x10⁻⁷—1.0x10⁻⁴ mol/L) were obtained for quality standard compound of isofraxidin. The precisions of the peak current and the migration time(as RSDs) for the real sample analysis were 2.0 % —2.6 % , and 1.2 % —1.8 % for isofraxidin, respectively. The contents of isofraxidin detected were 15.77 μg/tablet, 0.48 mg/capsule, 1.2 mg/ampoule(Jiangxi), and 0.44 mg/ampoule(Dalian) for Fufang Caoshanhu tablets, Qingrexiaoyanning capsules, and Xuekang oral liquids from different manufacturers, respectively. Quality estimate was conducted by comparing the contents of isofraxidin in the herbal medicine products with the demanded values of Chinese pharmacopeia. In addition, based on their own unique CE-ED profiles(namely, CE-ED electropherograms) the Xuekang oral liquids from the different manufacturers could be easily identified.