64Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133+ cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite
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- 作者：Yukie Yoshiia ; yukiey@nirs.go.jp" class="auth_mail" title="E-mail the corresponding author ; Takako Furukawaa ; Hiroki Matsumotob ; Mitsuyoshi Yoshimotoc ; Yasushi Kiyonod ; Ming-Rong Zhanga ; Yasuhisa Fujibayashia ; Tsuneo Sagaa
- 关键词：64Cu-ATSM ; DNA repair ; Nucleic acid antimetabolite ; Hypoxia ; Internal radiotherapy
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：376
- 期：1
- 页码：74-82
- 全文大小：1357 K
文摘
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64Cu-ATSM accumulates in tumor regions with upregulation of DNA repair.
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64Cu-ATSM high-uptake regions show enrichment of CD133+ cancer stem-like cells.
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Nucleic acid (NA) incorporation is facilitated in 64Cu-ATSM high-uptake regions.
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64Cu-ATSM therapy with an NA antimetabolite synergistically inhibited tumor growth.
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The sensitized 64Cu-ATSM therapy effectively reduced %CD133+ cells.