Short and flexible route to 3,4-diarylpyrrole marine alkaloids: syntheses of permethyl storniamide A, ningalin B, and lamellarin G trimethyl ether

详细信息    查看全文

• 作者：Iwao ; Masatomo ; Takeuchi ; Toshiro ; Fujikawa ; Naotaka ; Fukuda ; Tsutomu ; Ishibashi ; Fumito
• 刊名：Tetrahedron Letters
• 出版年：2003
• 出版时间：June 9, 2003
• 年：2003
• 卷：44
• 期：24
• 页码：4443-4446
• 全文大小：184 K

文摘

A highly efficient route to 3,4-diarylpyrrole marine alkaloids has been developed using Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki cross-coupling of the 3,4-dihydroxypyrrole bis-triflate derivatives as key reactions. Based on this approach, formal syntheses of permethyl storniamide A and ningalin B, and a total synthesis of lamellarin G trimethyl ether have been achieved.