Maintenance electroconvulsive therapy (ECT) for treatment-resistant disorganized schizophrenia

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• 作者：Eiji Shimizu ; Masao Imai ; Mihisa Fujisaki ; Naoyuki Shinoda ; Satoshi H ; a ; Hiroyuki Watanabe ; Michiko Nakazato ; Kenji Hashimoto ; Masaomi Iyo
• 关键词：Clozapine ; Electroconvulsive therapy ; Schizophrenia
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2007
• 出版时间：30 March 2007
• 年：2007
• 卷：31
• 期：2
• 页码：571-573
• 全文大小：100 K

文摘

Patients who have not responded to recommended antipsychotic medications should be considered for electroconvulsive therapy (ECT). However, there has been controversy about the standardized methods of continuation and maintenance ECT in the management of treatment-resistant schizophrenia. We describe a patient with a serious case of disorganized schizophrenia who had not responded well with any typical and atypical antipsychotic drug for seven years, but responded remarkably to acute ECT. Continuation ECT was necessary to sustain a positive therapeutic response. The patient showed dramatic improvement from 70 to 20 in the 18-item Brief Psychiatric Rating Scale (BPRS) score (71 % reduction) after acute ECT and continuation ECT. Using maintenance ECT, she was able to live in the custody of her parents after 7-years hospitalization. This case report suggests that continuation and maintenance ECT benefits patients with serious cases of refractory schizophrenia.