Effects of single and repeated stresses on the expression of mRNA for α₁-adrenoceptors in the rat hypothalamus and midbrain

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• 作者：Miyahara ; Satoru ; Komori ; Teruhisa ; Fujiwara ; Ryoichi ; Shizuya ; Koji ; Yamamoto ; Masato ; Ohmori ; Masaki ; et. al.
• 关键词：α ; ₁-Adrenoceptor ; Stress ; α ; -Adrenoceptor mRNA ; Hypothalamus ; Midbrain
• 刊名：European Journal of Pharmacology
• 出版年：1999
• 出版时间：August 20, 1999
• 年：1999
• 卷：379
• 期：1
• 页码：111-114
• 全文大小：164 K

文摘

We examined the effects of single or repeated stress on the expression of mRNA for α₁-adrenoceptors in the rat hypothalamus and midbrain using the reverse transcriptase-polymerase chain reaction (RT-PCR). Single stress significantly increased the mRNA level for α₁-adrenoceptors in the midbrain, but had no effect on mRNA levels in the hypothalamus. Repeated stress significantly decreased mRNA levels for α₁-adrenoceptors in both regions.