Genetic and epigenetic aberrations of p16 in feline primary neoplastic diseases and tumor cell lines of lymphoid and non-lymphoid origins

详细信息    查看全文

• 作者：H. Mochizuki ; ^{hmochiz@ncsu.edu} ; A. Fujiwara-Igarashi ; M. Sato ; Y. Goto-Koshino ; K. Ohno ; H. Tsujimoto
• 关键词：Cancer ; Cat ; Methylation ; p16
• 刊名：The Veterinary Journal
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：219
• 期：Complete
• 页码：27-33
• 全文大小：741 K
• 卷排序：219

文摘

The tumor suppressor p16 is frequently inactivated in human cancer but poorly investigated in feline cancer. The feline p16 gene was cloned, and its polymorphism was characterized in domestic cats. Epigenetic regulation of the p16 was demonstrated in feline lymphoma cell lines. Genetic and epigenetic alterations of p16 were detected in feline cancer cell lines and primary cancers. Frequent promoter methylation of the p16 gene was observed in feline B-cell lymphoid malignancies.