Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche
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- 作者：Masahiko Yamaguchi1 ; 7 ; Yoko Watanabe1 ; 7 ; Takuji Ohtani1 ; 7 ; Akiyoshi Uezumi2 ; Norihisa Mikami1 ; Miki Nakamura1 ; Takahiko Sato3 ; Masahito Ikawa4 ; Mikio Hoshino5 ; Kunihiro Tsuchida2 ; Yuko Miyagoe-Suzuki6 ; Kazutake Tsujikawa1 ; Shin&rsquo ; ichi Takeda6 ; Hiroshi Yamamoto1 ; So-ichiro Fukada1 ; fukada@phs.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：13
- 期：2
- 页码：302-314
- 全文大小：3112 K
文摘
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The calcitonin receptor (Calcr) maintains the adult MuSC pool
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The Calcr-cAMP-PKA pathway keeps MuSCs in their quiescent state
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Loss of Calcr allows emergence of MuSCs from their niche
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Calcr-cAMP-PKA and -Epac signaling inhibits emergence of MuSCs from their niche