BE360, a new selective estrogen receptor modulator, produces antidepressant and antidementia effects through the enhancement of hippocampal cell proliferation in olfactory bulbectomized mice
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- 作者：Osamu Nakagawasaia ; osamun@tohoku-pharm.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Wataru Nemotoa ; Hiroshi Onogib ; Takahiro Moriyac ; Jia-Rong Lina ; Takayo Odairaa ; Fukie Yaoitaa ; Takumi Ogawad ; Kiminori Ohtad ; Yasuyuki Endod ; Koichi Tan-Noa
- 关键词：Depression ; Memory ; Carborane compound ; Olfactory bulbectomy ; Cell proliferation ; Selective estrogen receptor modulator
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：315-322
- 全文大小：1915 K
文摘
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BE360 showed beneficial effects over depressive-like behavior and cognitive deficit in OBX mice.
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BE360 enhanced hippocampal cell proliferation in OBX mice.
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BE360 increased expression of pCREB and BDNF in hippocampus.
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BE360 has antidepressant and antidementia effect by hippocampal neurogenesis via CREB/BDNF signaling pathways.