P02: Carcinogenicity and in vivo

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• 作者：Shoji Fukushima ; Min Wei ; Masako Omori ; Keiichirou Morimura ; Anna Kinoshita ; Ken-ichi Masumura ; Takehiko Nohmi ; Hideki Wanibuchi
• 刊名：Experimental and Toxicologic Pathology
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：61
• 期：3
• 页码：282
• 全文大小：54 K

文摘

Spontaneous tumors of mammary gland are infrequent in male rats. A spontaneous adenocarcinoma of the mammary gland was observed in a 37-week-old male WNIN (Wistar/NIN) rat from the breeding colony of IIBAT. The rat had a subcutaneous mass at the left lateral aspect of neck measuring approximately 4 cm in diameter.

In our literature search, we did not find any reports of spontaneous malignant neoplasms of the male mammary gland in this age group. The histological features of this neoplasm are similar to those described in female rats, with the exception of a lack of functional differentiation.

Immunohistochemical staining of the tumor for smooth muscle actin and cytokeratin 14 was positive, which is consistent with a neoplasm of mammary origin.