Dermatoscopic vascular patterns in cutaneous Merkel cell carcinoma

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• 作者：Mandy S. Harting ; MD^a ; Mathew W. Ludgate ; MBChB ; FRACP^b ; Douglas R. Fullen ; MD^a ; ^c ; Timothy M. Johnson ; MD^a ; ^d ; ^e ; Christopher K. Bichakjian ; MD^a ; ^{chriskb@med.umich.edu}
• 关键词：atypical vascular pattern ; cutaneous malignancy ; dermatoscopy ; Merkel cell carcinoma ; neuroendocrine carcinoma ; skin cancer
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：66
• 期：6
• 页码：923-927
• 全文大小：590 K

文摘

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Background

Merkel cell carcinoma (MCC) is one of the most aggressive primary cutaneous malignancies. The clinical diagnosis of MCC is often delayed. Although the rarity of this skin cancer partially explains the low clinical suspicion by physicians, the absence of characteristic clinical features contributes to the delay in diagnosis. Dermatoscopy has proven a useful diagnostic tool in other cutaneous malignancies; however, the dermatoscopic features of cutaneous MCC are unknown.

Objective

We performed dermatoscopy on 10 primary cutaneous MCC to describe the dermatoscopic features and correlate these findings with the histopathologic parameters.

Methods

Consecutive patients with cutaneous MCC were identified and their tumors were evaluated under dermatoscopy. An 8-point MCC histopathology profile was recorded for each primary tumor in an attempt to correlate individual parameters with dermatoscopic features.

Results

All 10 tumors showed an irregular vascular pattern under dermatoscopy and demonstrated milky-red areas/globules and numerous linear irregular vessels. No correlation was noted between dermatoscopic and histopathologic features.

Limitations

The patients were from a single institution and tumors evaluated by a single dermatoscopic reviewer. Because of the rarity of this tumor, a small number of tumors were evaluated (10).

Conclusion

MCC exhibits a variety of dermatoscopic vascular patterns, most commonly milky-red areas/globules, polymorphous vessels, and linear-irregular vessels. Although we found no specific dermatoscopic pattern for MCC in our series, the polymorphous vascular pattern was atypical and suggestive of a malignant process. Further studies should be done to investigate the potential correlation between dermatoscopic features and histopathologic parameters.