Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman: A case report and review of the literature

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• 作者：Angella Charnot-Katsikas^a ; ^{Angella.Charnot-Katsikas@uchospitals.edu" class="auth_mail" title="E-mail the corresponding author} ; David Baewer^b ; ^{dbaewer@coppehealth.com" class="auth_mail" title="E-mail the corresponding author} ; Linda Cook^c ; ^{lincook@u.washington.edu" class="auth_mail" title="E-mail the corresponding author} ; Michael Z. David^d ; ^{mdavid@medicine.bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ALF ; acute liver failure ; ALP ; alkaline phosphatase ; ALT ; alanine aminotransferase ; ANA ; antinuclear antibody ; AST ; aspartate aminotransferase ; ATN ; acute tubular necrosis ; AV ; atrioventrivular ; AZ ; azithromycin ; CF ; ceftriaxone ; CL ; clindamycin ; CMV ; cytomegalovirus ; CRP ; C-reactive protein ; CT ; computed tomography ; DIHS ; drug-Induced hypersensitivity syndrome ; DNA ; deoxyribonucleic acid ; EBV ; Epstein Barr virus ; EF ; ejection fraction ; FH ; fulminant hepatitis ; GC ; ganciclovir ; HHV-6 ; human herp
• 刊名：Journal of Clinical Virology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：75
• 期：Complete
• 页码：27-32
• 全文大小：1452 K

文摘

Mild disease due to human herpesvirus-6 (HHV-6) has been reported in healthy children. Severe disease due to this virus can occur in immunocompromised patients but is rarely reported in previously healthy adults. We report the case of a previously healthy woman who presented with a skin rash, mild upper respiratory symptoms, and abdominal pain and succumbed to fulminant hepatic failure attributed to infection with HHV-6B.

HHV-6 may be more commonly associated with fulminant hepatitis in immunocompetent patients than previously thought and should be considered in the differential diagnosis of patients presenting with skin rash, upper respiratory symptoms, and unexplained hepatitis.