• 作者：Hoang van Tong^a ; ^{tong.van-hoang@uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author} ; Nghiem Xuan Hoan^a ; Bo Wang^b ; Heiner Wedemeyer^c ; C.-Thomas Bock^b ; ¹ ; ^{bockc@rki.de" class="auth_mail" title="E-mail the corresponding author} ; Thirumalaisamy P. Velavan^a ; ¹
• 关键词：HEV ; hepatitis E virus ; ORF ; open reading frame ; MeT ; methyltransferase ; Y ; Y-domain ; PCP ; papain-like cysteine protease ; HVR ; hypervariable region ; X-domain ; macro-domain ; Hel ; RNA helicase ; RdRp ; RNA-dependent RNA polymerase ; PPR ; polyproline region ; CP ; capsid protein ; aa ; amino acid ; vgRNA ; viral genomic RNA ; sgRNA ; sub-genomic RNA ; CRE ; cis-reactive element
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：11
• 期：Complete
• 页码：31-42
• 全文大小：789 K

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HEV causes acute hepatitis and recently comes into focus because of persistent infection in immunocompromised patients.

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HEV variability can be associated with clinical pathogenesis and transmission dynamics.

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Mutations in the HEV genome can influence HEV physiology and virus-host interaction.

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HEV mutations and variability are likely associated with fulminant hepatic failure and chronic hepatitis E.

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The Y1320H and G1634R/K mutations in the RdRp domain contribute to antiviral resistance through enhancing HEV replication.

We searched MEDLINE database and PubMed for articles from 1980 through June 30, 2016. Search terms used in various combinations were “hepatitis E”, “hepatitis E virus”, “hepatitis E virus infection”, “hepatitis E virus mutation”, “HEV variability”, “HEV genotype”, “HEV drug resistance”, “HEV replication” and “ribavirin”. Articles resulting from these searches and relevant references cited in those articles were selected based on their related topics and were reviewed. Abstracts and reports from meetings were also included. Articles published in English were included.