The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy
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- 作者：Tomoya Kitakazea ; 1 ; Tomotaka Sakamotoa ; 1 ; Takehiro Kitanoa ; Naoki Inoueb ; Fumihito Sugiharab ; Naoki Haradaa ; Ryoichi Yamajia ; yamaji@biochem.osakafu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Differentiation ; Myoblast ; Myotube ; Collagen peptide ; Hydroxyprolyl-glycine ; Hypertrophy
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1292-1297
- 全文大小：704 K
文摘
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Hyp-Gly promotes myogenic differentiation and increases myotube size.
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Hyp-Gly induces the phosphorylation of Akt, mTOR, and p70S6K.
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Hyp-Gly seems to promote myogenic differentiation by activating the mTOR pathway.
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Hyp-Gly-induced phosphorylation of p70S6K is inhibited by histidine.