Controlling noncovalent interactions between a lysine-rich α-helical peptide and self-assembled monolayers of alkanethiols on Au through functional group diversity

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• 作者：Annette F. Raigoza¹ ; Kristeen Onyirioha ; Lauren J. Webb ; ^{lwebb@cm.utexas.edu}
• 关键词：Protein surface functionalization ; Self-assembled monolayers ; Huisgen cycloaddition &ldquo ; click&rdquo ; chemistry ; Surface spectroscopy ; Langmuir isotherms
• 刊名：Applied Surface Science
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：396
• 期：Complete
• 页码：1831-1839
• 全文大小：1977 K
• 卷排序：396

文摘

Functional variety in SAMs control covalent binding of proteins to surfaces. Peptide density on Au(111) surfaces controlled by SAM functional groups. Affinity between biomolecule and SAM surface follows a Langmuir isotherm. Surface chemistry can mimic functional group diversity in proteins and peptides.