Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
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- 作者：S. Mitomo1 ; T. Omatsu1 ; S. Tsuchiaka ; M. Nagai ; T. Furuya ; T. Mizutani ; tmizutan@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Akabane virus ; Apoptosis ; Mitogen-activated protein kinase (MAPK)
- 刊名：Research in Veterinary Science
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：147-151
- 全文大小：777 K
文摘
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id="p0005">JNK and p38 MAPK were phosphorylated in response to Akabane virus infection.
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id="p0010">Downstream substrates, c-Jun and heat shock protein 27, were also phosphorylated by viral infection.
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id="p0015">JNK inhibitor (SP600125) inhibited AKAV-mediated apoptosis whereas a p38 MAPK inhibitor (SB203580) did not.