Inversion at the Bridgehead Nitrogen of the 1-Azabicyclo[4.4.0]decane Ring System

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• 作者：Slough ; Greg A. ; Han ; Fusen ; Lee ; Byung H.
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：May 14, 1999
• 年：1999
• 卷：40
• 期：20
• 页码：3851-3854
• 全文大小：151 K

文摘

Single crystal X-ray analyses conducted on 14-(R)-hydroxymarcfortine A 2 containing a 1-azabicyclo[4.4.0]decane ring system showed the unit cell to consist of two invertomers which differ in conformation at the bridgehead nitrogen. When the proton NMR spectra of 2 were recorded at low temperatures separate signals for each invertomer were observed.