Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics
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- 作者：Cory Stiff ; David R. Graber ; Atli Thorarensen ; Brian D. Wakefield ; Keith R. Marotti ; Earline P. Melchior ; Michael T. Sweeney ; Fusen Han ; Douglas C. Rohrer ; Gary E. Zurenko ; Donna L. Romero
- 关键词：Bioisosteres ; Translation inhibitors ; Antibacterials ; Indazol ; Protein binding
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：1 December 2008
- 年：2008
- 卷：18
- 期：23
- 页码：6293-6297
- 全文大小：220 K
文摘
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure–activity relationships of the indazol bioisosteres are described herein.