Risk of infectious complications associated with blood transfusion in elective spinal surgery—a propensity score matched analysis

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• 作者：So Kato ; MD^a ; ^{skatou-tky@umin.org" class="auth_mail" title="E-mail the corresponding author} ; Hirotaka Chikuda ; MD ; PhD^a ; Junichi Ohya ; MD^a ; Takeshi Oichi ; MD^a ; Hiroki Matsui ; MPH^b ; Kiyohide Fushimi ; MD ; PhD^c ; Katsushi Takeshita ; MD ; PhD^a ; Sakae Tanaka ; MD ; PhD^a ; Hideo Yasunaga ; MD ; PhD^b
• 关键词：Adverse impact ; Blood transfusion ; Complication ; Infection ; Lumbar surgery ; National database ; Patient blood management ; Propensity score ; Surgical site infection ; Urinary tract infection
• 刊名：The Spine Journal
• 出版年：2016
• 出版时间：1 January 2016
• 年：2016
• 卷：16
• 期：1
• 页码：55-60
• 全文大小：204 K

文摘

Although the negative aspects of blood transfusion are increasingly recognized, less is known about transfusion-related risks in spinal surgery.

Purpose

This study was designed to determine whether perioperative allogeneic blood transfusion is associated with increased risk of infectious complications after elective spinal surgery.

Study Design

A retrospective cohort study with propensity score matched analysis was carried out.

Patient Sample

Data of patients with spinal canal stenosis and spondylolisthesis who underwent elective lumbar surgeries (decompression or fusion) were obtained from the Diagnosis Procedure Combination database, a nationwide administrative inpatient database in Japan.

Outcome Measures

Clinical outcomes included in-hospital death and the occurrence of infectious complications (surgical site infection [SSI], respiratory tract infection, urinary tract infection, and sepsis).

Methods

Patients' clinical information, including sex, age, type of hospital, preoperative comorbidities, duration of anesthesia, cell saver use, and volume of allogeneic blood transfused, were investigated. Patients transfused with >840 mL (6 units) were excluded. Propensity scores for receiving transfusion were calculated, with one-to-one matching based on estimated propensity scores to adjust for patients' baseline characteristics. The proportions of complications were compared in patients with and without transfusions. This study was funded by grants from the Ministry of Health, Labour and Welfare, Japan.

Results

Of the 84,650 patients identified, 5,289 patients (6.1%) received transfusions, with 4,436 (5.2%) receiving up to 840 mL. One-to-one propensity score matching resulted in 4,275 pairs with and without transfusion. Patients transfused were at increased risk of SSI (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.4–2.5; p<.001) and urinary tract infection (OR, 2.5; 95% CI, 1.5–4.2; p<.001) than those not transfused.

Conclusions

Allogeneic blood transfusion after elective lumbar surgery was associated with increased risks of SSI and urinary tract infection.