Exploring Polyubiquitin as a Flexible Multiple-Ligand Binding Platform

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• 作者：David Fushman¹ ; ^{fushman@umd.edu}
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：1-3
• 全文大小：596 K
• 卷排序：25

文摘

Linear (head-to-tail linked) polyubiquitin chains play a key role in the regulation of NF-κB signaling. In this issue of Structure, Lin et al. (2017) shed light on how linear tri-ubiquitin binds to ABIN2, a molecule that shares ubiquitin-binding properties of NEMO, the key activator of NF-κB.