RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro

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• 作者：Tsung-Jen Liao¹ ; ² ; Chung-Jung Tsai¹ ; Hyunbum Jang¹ ; David Fushman² ; ³ ; Ruth Nussinov¹ ; ⁴ ; ^{nussinor@helix.nih.gov}
• 刊名：Current Opinion in Structural Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：217-224
• 全文大小：1436 K
• 卷排序：41

文摘

RASSF5 links Ras and the Hippo pathway whose signaling leads to YAP degradation. YAP1 overexpression promotes cancer. Most reports point to RASSF5 suppressing cancer; however, some to promoting cancer. We propose that RASSF5 acts as an adaptor protein. RASSF5 activates MST and suppress cancer in vivo; but inhibit signaling in vitro.