NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis

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• 作者：Haiming Xu¹ ; ² ; ⁵ ; ^{haiming_xu@dfci.harvard.edu} ; Daria G. Valerio¹ ; ⁵ ; Meghan E. Eisold¹ ; Amit Sinha¹ ; Richard P. Koche¹ ; Wenhuo Hu³ ; Chun-Wei Chen¹ ; ² ; S. Haihua Chu¹ ; ² ; Gerard L. Brien¹ ; ² ; Christopher Y. Park³ ; James J. Hsieh³ ; Patricia Ernst⁴ ; Scott A. Armstrong¹ ; ² ; ⁶ ; ^{scott_armstrong@dfci.harvard.edu}
• 关键词：NUP98 fusion ; mixed lineage leukemia 1 ; non-specific lethal histone-modifying complexes ; leukemia ; Hox gene
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：12 December 2016
• 年：2016
• 卷：30
• 期：6
• 页码：863-878
• 全文大小：3390 K
• 卷排序：30

文摘

NUP98 fusions interact with MLL1 and NSL histone-modifying complexes NUP98 fusions and MLL1 co-localize at Hoxa and Hoxb cluster gene loci MLL1 is required for NUP98-HOXA9-induced leukemogenesis in vitro and in vivo MLL1-dependent gene expression signatures resemble human NUP98-NSD1 AML