Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse

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• 作者：Tervonen ; Topi ; ??kerman ; Karl ; Oostra ; Ben A. ; Castr??n ; Maija
• 关键词：Development and regeneration ; Process outgrowth ; growth cones ; and sprouting ; Regulator for G-protein signaling 4 ; Regulator for G-protein signaling 2 ; FMRP ; Fmr1 knockout mouse ; In situ hybridization ; Gene expression
• 刊名：Molecular Brain Research
• 出版年：2005
• 出版时间：January 5, 2005
• 年：2005
• 卷：133
• 期：1
• 页码：162-165
• 全文大小：315 K

文摘

In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65 % from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.