Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
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- 作者：Crystal Bostroma ; Suk-yu Yaub ; Namat Majaessa ; Mariana Vetricia ; Joana Gil-Mohapela ; c ; Brian R. Christiea ; c ; brain64@uvic.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPAR ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ; ASD ; autism spectrum disorder ; BrdU ; 5-bromo-2&prime ; -deoxyuridine ; CA ; cornu ammonis ; CaMKII ; calcium/calmodulin-dependent protein kinase II ; CGG ; cytosine-guanine-guanine ; DG ; dentate gyrus ; DHPG ; (S)-3 ; 5-dihydroxyphenylglycine ; EPSCs ; excitatory postsynaptic currents ; Fmr1 ; Fragile X Mental Retardation 1 ; FMRP ; Fragile X Mental Retardation Protein ; FXS ; Fragile-X Syndrome ; GABA ; γ-aminobutyric acid ; GSK3β ; glycogen synthase
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：563-574
- 全文大小：1417 K
文摘
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Fmr1 KO mice show abnormal spine density, length and morphology in the hippocampus.
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Fmr1 KO mice present alterations in neurogenesis in the hippocampal dentate gyrus.
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Exaggerated mGluR-dependent LTD occurs in the hippocampal CA1 of Fmr1 KO mice.
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Hypofunction of NMDA receptors occurs in the hippocampal DG of Fmr1 KO mice.
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Deficits in hippocampal plasticity may underlie behavioural abnormalities in FXS.