APC/C^Fzr/Cdh1-Dependent Regulation of Planar Cell Polarity Establishment via Nek2 Kinase Acting on Dishevelled

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• 作者：Ursula Weber¹ ; Marek Mlodzik¹ ; ² ; ^{marek.mlodzik@mssm.edu}
• 关键词：anaphase-promoting complex ; post-mitotic function ; planar cell polarity ; Drosophila ; asymmetric protein localization ; Nek2 kinase ; proteasome-mediated degradation
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：53-66
• 全文大小：6318 K
• 卷排序：40

文摘

Post-mitotic Anaphase-Promoting Complex (APC) function in planar cell polarity APC regulates the function of Nek2 during planar cell polarity (PCP) establishment Dishevelled (Dsh) is the core PCP target of the APC/C during PCP signaling APC regulates Nek2 levels and Nek2 regulates Dsh via phosphorylation