Oncogenic Signaling Adaptor Proteins

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• 作者：Leo Y. Luo^a ; William C. Hahn^b ; ^c ; ^d ; ^e ; ^{William_Hahn@dfci.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Adaptor protein ; Cancer ; Oncogene
• 刊名：Journal of Genetics and Genomics
• 出版年：2015
• 出版时间：20 October 2015
• 年：2015
• 卷：42
• 期：10
• 页码：521-529
• 全文大小：428 K

文摘

Signal transduction pathways activated by receptor tyrosine kinases (RTK) play a critical role in many aspects of cell function. Adaptor proteins serve an important scaffolding function that facilitates key signaling transduction events downstream of RTKs. Recent work integrating both structural and functional genomic approaches has identified several adaptor proteins as new oncogenes. In this review, we focus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes, CRKL, GAB2, and FRS2. Each of the three genes is recurrently amplified in lung adenocarcinoma or ovarian cancer, and is essential to cancer cell lines that harbor such amplification. Overexpression of each gene is able to transform immortalized human cell lines in in vitro or in vivo models. These observations identify adaptor protein as a distinct class of oncogenes and potential therapeutic targets.