Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia
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- 作者：Christoph Bodea ; 1 ; Franziska Richtera ; 1 ; franziska.richter@vmf.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Christine Sprö ; tea ; Tanja Brigadskib ; c ; Anne Bauera ; Simone Fietzd ; Jean-Marc Fritschye ; Angelika Richtera ; angelika.richter@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; CAVII ; cytosolic carboanhydrase isotyp 7 ; GABAAR ; GABAA receptor ; IN ; interneurons ; PV ; parvalbumin ; KCC2 ; potassium chloride transporter 2
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：44-53
- 全文大小：2053 K
文摘
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Striatal parvalbumin expression is decreased in the dystonic hamster model.
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Density of Nkx2.1 labeled striatal interneurons was unchanged in dystonic hamsters.
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BDNF and GABA-switch expression levels were not altered in dystonic hamsters.
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GABAAR-α1 positive striatal neurons were transiently reduced in dystonic hamsters.
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Retarded interneuron maturation could be involved in pathophysiology of dystonia.